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M9630382.TXT
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1996-02-27
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Document 0382
DOCN M9630382
TI Hot water extracts of Chlorella vulgaris reduce opportunistic infection
with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine
leukemia viruses.
DT 9603
AU Hasegawa T; Okuda M; Makino M; Hiromatsu K; Nomoto K; Yoshikai Y;
Laboratory of Host Defense and Germfree Life, Nagoya University; School
of Medicine, Japan.
SO Int J Immunopharmacol. 1995 Jun;17(6):505-12. Unique Identifier :
AIDSLINE MED/96022699
AB The bacterial elimination after infection with Listeria monocytogenes
was impaired in mice with murine acquired immunodeficiency syndrome
(MAIDS) by infection with LP-BM5 murine leukemia virus. Oral
administration of hot water extracts of Chlorella vulgaris (CVE)
restored the capacity of MAIDS mice to eliminate L. monocytogenes in
association with improvement of the deteriorated immune response to L.
monocytogenes. DTH response to Listeria in CVE-treated MAIDS mice was
significantly higher than that of MAIDS mice after Listeria infection in
association with increases in number of CD4+CD8- and CD4-CD8+ alpha beta
T-cells in the infected sites. CVE might be effective in the treatment
of opportunistic infection in retrovirus-induced immunodeficient
patients.
DE Animal Chlorella/*CHEMISTRY Female Hypersensitivity,
Delayed/IMMUNOLOGY *Leukemia Viruses, Murine/DRUG EFFECTS Leukemia,
Experimental/COMPLICATIONS Listeria monocytogenes/GROWTH &
DEVELOPMENT/IMMUNOLOGY Listeria
Infections/COMPLICATIONS/IMMUNOLOGY/*PREVENTION & CONTROL Mice Mice,
Inbred C57BL Murine Acquired Immunodeficiency Syndrome/COMPLICATIONS
Opportunistic Infections/COMPLICATIONS/IMMUNOLOGY/*PREVENTION & CONTROL
Plant Extracts/*THERAPEUTIC USE T-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY
Tumor Virus Infections/COMPLICATIONS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).